ChloroquineV1, Main, Exploration, bibRecord, 003421

Potential radiopharmaceuticals for the detection of ocular melanoma

Identifieur interne : 003421 ( Main/Exploration ); précédent : 003420; suivant : 003422

Potential radiopharmaceuticals for the detection of ocular melanoma

Auteurs : A. Van Langevelde [Pays-Bas] ; C. N. M. Bakker [Pays-Bas] ; H. Boer [Pays-Bas] ; T. A. M. Ilmer [Pays-Bas] ; J. A. Journée-De Korver [Pays-Bas] ; F. M. Kaspersen [Pays-Bas] ; E. L. Noach [Pays-Bas] ; J. A. Oosterhuis [Pays-Bas] ; E. K. J. Pauwels [Pays-Bas]

Source :

European Journal of Nuclear Medicine [ 0340-6997 ] ; 1986-06-01.

RBID : ISTEX:96759FB97B2FDABEDDFEBF43C2EF157C7F31FE7F

English descriptors

KwdEn :
- 67Ga-citrate, Iodoquinolines, Melanoma.
Teeft :
- Activity dose, Amino group, Bakker, Beierwaltes, Blood tumour, Cell cultures, Chloroquine, Derivative, Different time intervals, Ether anaesthesia, Excretion, Further experiments, Gram organ, Gram tissue, Gram tumour, Greene melanoma, Hamster, High affinity, High uptake, Injection, Iodoquinoline, Iodoquinolines, Kaspersen, Melanin, Melanoma, Melanoma cells, Melanoma detection, Metabolism, Nucl, Ocular, Ocular melanoma, Ocular melanomas, Oral administration, Orbital bone, Organ distribution, Packer, Parent compound, Patient studies, Pauwels, Phenobarbital, Quinoline, Quinoline ring, Radiopharmaceutical, Ratios tumour, Significant differences, Syrian, Tumour, Uptake, Uptake percentage, Uptake percentages.

Abstract

Abstract: The uptake and distribution of several 4-(substituted amino)-iodoquinolines, 131I-labelled, and of 67Ga-citrate were investigated in Syrian golden hamsters with Greene melanomas. Because of its uptake in the melanoma (tumour/eye ratio 8.9), 4-(dimethylamino-ethylamino)-7-iodoquinoline (NM113) was selected for further investigations as a possible radiopharmaceutical for ocular scintigraphy when labelled with 123I. High uptake of NM113 turned out to be incidental and could not be favourably influenced by several pharmacological pretreatments. Affinity for melanin, as shown in in vitro experiments, unfavourably influences NM113 tumour-to-eye ratios. In comparison with 67Ga-citrate, the latter, with a high tumour-to-eye ratio (44.8 after 24 h) is more promising in patient studies in which NM113 123I was not.

Url:

https://api.istex.fr/ark:/67375/1BB-TX7L8NXH-B/fulltext.pdf

DOI: 10.1007/BF00364737

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000772
to stream Istex, to step Curation: 000772
to stream Istex, to step Checkpoint: 002180
to stream Main, to step Merge: 003494
to stream Main, to step Curation: 003421

Le document en format XML

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<author><name sortKey="Noach, E L" sort="Noach, E L" uniqKey="Noach E" first="E. L." last="Noach">E. L. Noach</name>
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<author><name sortKey="Oosterhuis, J A" sort="Oosterhuis, J A" uniqKey="Oosterhuis J" first="J. A." last="Oosterhuis">J. A. Oosterhuis</name>
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<author><name sortKey="Pauwels, E K J" sort="Pauwels, E K J" uniqKey="Pauwels E" first="E. K. J." last="Pauwels">E. K. J. Pauwels</name>
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<series><title level="j">European Journal of Nuclear Medicine</title>
<title level="j" type="abbrev">Eur J Nucl Med</title>
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<pubPlace>Berlin/Heidelberg</pubPlace>
<date type="published" when="1986-06-01">1986-06-01</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>67Ga-citrate</term>
<term>Iodoquinolines</term>
<term>Melanoma</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Activity dose</term>
<term>Amino group</term>
<term>Bakker</term>
<term>Beierwaltes</term>
<term>Blood tumour</term>
<term>Cell cultures</term>
<term>Chloroquine</term>
<term>Derivative</term>
<term>Different time intervals</term>
<term>Ether anaesthesia</term>
<term>Excretion</term>
<term>Further experiments</term>
<term>Gram organ</term>
<term>Gram tissue</term>
<term>Gram tumour</term>
<term>Greene melanoma</term>
<term>Hamster</term>
<term>High affinity</term>
<term>High uptake</term>
<term>Injection</term>
<term>Iodoquinoline</term>
<term>Iodoquinolines</term>
<term>Kaspersen</term>
<term>Melanin</term>
<term>Melanoma</term>
<term>Melanoma cells</term>
<term>Melanoma detection</term>
<term>Metabolism</term>
<term>Nucl</term>
<term>Ocular</term>
<term>Ocular melanoma</term>
<term>Ocular melanomas</term>
<term>Oral administration</term>
<term>Orbital bone</term>
<term>Organ distribution</term>
<term>Packer</term>
<term>Parent compound</term>
<term>Patient studies</term>
<term>Pauwels</term>
<term>Phenobarbital</term>
<term>Quinoline</term>
<term>Quinoline ring</term>
<term>Radiopharmaceutical</term>
<term>Ratios tumour</term>
<term>Significant differences</term>
<term>Syrian</term>
<term>Tumour</term>
<term>Uptake</term>
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<front><div type="abstract" xml:lang="en">Abstract: The uptake and distribution of several 4-(substituted amino)-iodoquinolines, 131I-labelled, and of 67Ga-citrate were investigated in Syrian golden hamsters with Greene melanomas. Because of its uptake in the melanoma (tumour/eye ratio 8.9), 4-(dimethylamino-ethylamino)-7-iodoquinoline (NM113) was selected for further investigations as a possible radiopharmaceutical for ocular scintigraphy when labelled with 123I. High uptake of NM113 turned out to be incidental and could not be favourably influenced by several pharmacological pretreatments. Affinity for melanin, as shown in in vitro experiments, unfavourably influences NM113 tumour-to-eye ratios. In comparison with 67Ga-citrate, the latter, with a high tumour-to-eye ratio (44.8 after 24 h) is more promising in patient studies in which NM113 123I was not.</div>
</front>
</TEI>
<affiliations><list><country><li>Pays-Bas</li>
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<region><li>Hollande-Méridionale</li>
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<name sortKey="Journee De Korver, J A" sort="Journee De Korver, J A" uniqKey="Journee De Korver J" first="J. A." last="Journée-De Korver">J. A. Journée-De Korver</name>
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<name sortKey="Van Langevelde, A" sort="Van Langevelde, A" uniqKey="Van Langevelde A" first="A." last="Van Langevelde">A. Van Langevelde</name>
</country>
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Potential radiopharmaceuticals for the detection of ocular melanoma

Potential radiopharmaceuticals for the detection of ocular melanoma

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri